Analysis of pm 2.5 exposure impact in different atmospheric contexts: a detailed fem simulation analysis in a virtual LOAC device

Abstract

PM 2.5 concentration is a significant factor in fine particulate matter pollution, causing adverse health impacts, particularly respiratory health. Different sources of PM 2.5 pollutants can also damage human lungs. A comparative impact analysis on lungs in high and low-AQI-ranked cities can help regenerate urban air quality improvement guidelines and future land-use planning. A study of human lung mechanism simulation using a microfluidic device's virtual 3D model called Lung on a Chip (LOAC), by analyzing fine particle transport, deposition, cell uptake, and inflammatory response, shows how changes in PM 2.5 concentration cause damage to health conditions. The deposition level is not proportional to the PM 2.5 concentration; it depends on the source, breathing style, outdoor exposure, and exposure duration. This research helps identify harmful PM 2.5 concentration thresholds and guides future research on healthy zoning in future cities, considering air quality's impact on human health in urban areas.