A Theoretical model for thrombin generation kinetics in the initial phase of the extrinsic pathway of human blood coagulation

Abstract

This approach presents a nonlinear theoretical model to predict the thrombin concentration in the initial phase kinetics of the extrinsic pathway of human blood coagulation. The model integrates key enzymatic reactions and the positive feedback mechanism of the extrinsic pathway to simulate thrombin generation and factor activation dynamics. The presented model accurately predicts thrombin concentration over time under the assumptions based on the initial conditions. However, upon fibrinolysis activation, deviations arise due to fluctuating concentrations of plasminogen activators and inhibitors. These findings underscore the model's utility in understanding hemostasis regulation and highlight the need for further refinement to incorporate fibrinolysis dynamics for comprehensive insights for continuous modeling.