Association between BRCA1 promoter methylation in peripheral blood DNA and sporadic breast cancer risk in postmenopausal women

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dc.contributor.authorKrishnasamy, K
dc.contributor.authorSirisena, ND
dc.date.accessioned2026-03-24T05:41:57Z
dc.date.issued2025
dc.description.abstractBreast cancer is a multifaceted disease resulting from genetic and epigenetic changes. Although pathogenic mutations in the BRCA1 gene are thoroughly studied, the methylation of its promoter, which leads to epigenetic silencing, has also surfaced as a possible alternative mechanism that influences gene expression and tumor formation. The study aims to determine the association between germline BRCA1 gene promoter methylation and sporadic breast cancer
dc.identifier.conferenceAnnual Academic Sessions-2025
dc.identifier.doihttps://doi.org/10.31705/FOMAAS.2025.045
dc.identifier.facultyMedicine
dc.identifier.pgnos50p.
dc.identifier.placeMoratuwa
dc.identifier.proceedingAnnual Academic Sessions of the Faculty of Medicine, University of Moratuwa
dc.identifier.urihttps://dl.lib.uom.lk/handle/123/25019
dc.language.isoen
dc.publisherFaculty of Medicine, University of Moratuwa
dc.subjectDNA METHYLATION
dc.subjectBRCA1
dc.subjectBREAST CANCER
dc.subjectPROMOTER REGION
dc.subjectMETHYLATION SPECIFIC PCR
dc.titleAssociation between BRCA1 promoter methylation in peripheral blood DNA and sporadic breast cancer risk in postmenopausal women
dc.typeConference-Abstract

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